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Target
Microtubule-associated proteins 1A/1B light chain 3B
Ligand
BDBM500146
Substrate
n/a
Meas. Tech.
Assay Targeting LC3B
IC50
<3±n/a nM
Citation
 Yao, Z; Luo, C; Xie, Y; Yue, L; Wan, W; Zhang, Y; Jiang, H; Chen, K Class of isoindolone-imide ring-1,3-dione-2-ene compounds, composition and use thereof US Patent  US11021457 Publication Date 6/1/2021 
Target
Name:
Microtubule-associated proteins 1A/1B light chain 3B
Synonyms:
Autophagy-related protein LC3 B | Autophagy-related ubiquitin-like modifier LC3 B | MAP1 light chain 3-like protein 2 | MAP1A/MAP1B LC3 B | MAP1A/MAP1B light chain 3 B | MAP1ALC3 | MAP1LC3B | MLP3B_HUMAN | Microtubule-associated protein 1 light chain 3 beta
Type:
Protein
Mol. Mass.:
14691.38
Organism:
Human
Description:
Q9GZQ8
Residue:
125
Sequence:
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFGMKLSV
  
Inhibitor
Name:
BDBM500146
Synonyms:
US11021457, Compound 158
Type:
Small organic molecule
Emp. Form.:
C35H33Cl2F3N6O7
Mol. Mass.:
777.574
SMILES:
FC(F)(F)c1ccc(Cl)c(C2CC(=O)C(=CNCCN3CCN(CC(=O)Nc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)C(=O)C2)c1Cl |(11.38,-3.96,;10.05,-4.73,;10.82,-6.06,;9.28,-3.39,;8.72,-5.5,;8.67,-7.06,;7.34,-7.83,;6,-7.06,;4.67,-7.83,;6,-5.52,;4.67,-4.75,;3.33,-5.52,;2,-4.75,;.67,-5.52,;2,-3.21,;.67,-2.44,;-.67,-3.21,;-2,-2.44,;-3.33,-3.21,;-4.67,-2.44,;-6,-3.21,;-7.34,-2.44,;-7.34,-.9,;-8.67,-.13,;-8.67,1.41,;-7.34,2.18,;-10,2.18,;-10,3.72,;-11.34,4.49,;-11.34,6.03,;-10,6.8,;-8.67,6.03,;-7.2,6.5,;-6.43,7.83,;-6.3,5.26,;-4.76,5.26,;-3.99,6.59,;-2.45,6.59,;-1.68,5.26,;-.14,5.26,;-2.45,3.92,;-3.99,3.92,;-4.76,2.59,;-7.2,4.01,;-6.43,2.68,;-8.67,4.49,;-6,-.13,;-4.67,-.9,;3.33,-2.44,;3.33,-.9,;4.67,-3.21,;7.34,-4.75,;7.34,-3.21,)|
Structure:
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