Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM7937
Substrate
BDBM7883
Meas. Tech.
QC Inhibition Testing
Ki
90±n/a nM
Citation
Buchholz, M; Heiser, U; Schilling, S; Niestroj, AJ; Zunkel, K; Demuth, HU The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem 49:664-77 (2006) [PubMed] Article
More Info.:
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
Inhibitor
Name:
BDBM7937
Synonyms:
1-(3,4-dimethoxyphenyl)-N-[3-(1H-imidazol-1-yl)propyl]cyclopropane-1-carbothioamide | N-(3-(1H-Imidazol-1-yl)propyl)-1-(3,4-dimethoxyphenyl)cyclopropanecarbothioamide | thioamide deriv. 81
Type:
Small organic molecule
Emp. Form.:
C18H23N3O2S
Mol. Mass.:
345.459
SMILES:
COc1ccc(cc1OC)C1(CC1)C(=S)NCCCn1ccnc1