| Reaction Details |
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 | Report a problem with these data |
| Target | Egl nine homolog 1 |
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| Ligand | BDBM500335 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Effect of Compounds on Activities of HIF Prolyl Hydroxylase-2 |
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| IC50 | 800±n/a nM |
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| Citation |  Liu, D; Chen, D; Deng, B; Tu, X; Fang, Z; Wu, H; Gu, D Indolizine derivatives and their application in medicine US Patent US11021478 Publication Date 6/1/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Egl nine homolog 1 |
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| Name: | Egl nine homolog 1 |
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| Synonyms: | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2) |
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| Type: | Protein |
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| Mol. Mass.: | 46035.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9GZT9 |
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| Residue: | 426 |
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| Sequence: | MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQG
SEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADP
AAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLR
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQL
VSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMV
ACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKF
DRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDS
VGKDVF
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| BDBM500335 |
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| Name | BDBM500335 |
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| Synonyms: | US11021478, Example 30 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N2O5 |
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| Mol. Mass. | 358.3884 |
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| SMILES | OC(=O)CNC(=O)C1=C(O)C2(CCCCC2)n2c(ccc2C1=O)C1CC1 |c:7| |
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| Structure |  |
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| n/a |
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