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Target
Egl nine homolog 1
Ligand
BDBM500339
Substrate
n/a
Meas. Tech.
Effect of Compounds on Activities of HIF Prolyl Hydroxylase-2
IC50
600±n/a nM
Citation
 Liu, D; Chen, D; Deng, B; Tu, X; Fang, Z; Wu, H; Gu, D Indolizine derivatives and their application in medicine US Patent  US11021478 Publication Date 6/1/2021 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM500339
Synonyms:
(1''-Cyclopropyl-6''-hydroxy-8''-oxo-8''H-spiro[cyclohexane-1,5''-indolizine]-7''-carbonyl)glycine (52) and (2''-Cyclopropyl-6''-hydroxy-8''-oxo-8''H-spiro[cyclohexane-1,5''-indolizine]-7''-carbonyl)glycine (53) | US11021478, Example 52 | US11021478, Example 53 | US11655249, Example 53
Type:
Small organic molecule
Emp. Form.:
C19H22N2O5
Mol. Mass.:
358.3884
SMILES:
OC(=O)CNC(=O)C1=C(O)C2(CCCCC2)n2ccc(C3CC3)c2C1=O |c:7|
Structure:
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