Reaction Details Report a problem with these data
Target
Stimulator of interferon genes protein [139-379,H232R]
Ligand
BDBM501363
Substrate
n/a
Meas. Tech.
STING SPR Binding Assay
Kd
1.70±n/a nM
Citation
 Emanuel, S; Richter, M; Connolly, PJ; Edwards, JP; Wang, G; Thatikonda, SK; Beigelman, L; Zhong, M; Bignan, G Cyclic dinucleotides as sting agonists US Patent  US11021511 Publication Date 6/1/2021 
Target
Name:
Stimulator of interferon genes protein [139-379,H232R]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein (aa 139-379 H232R) | TMEM173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27090.78
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
241
Sequence:
LAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM501363
Synonyms:
US11021511, Compound 6b
Type:
Small organic molecule
Emp. Form.:
C21H25FN10O10P2S2
Mol. Mass.:
722.56
SMILES:
CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12 |r|
Structure:
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