Reaction Details
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Protein-arginine deiminase type-4
Ligand
BDBM501520
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
70000±n/a nM
Citation
Devraj, R; Kumaravel, G; Lecci, C; Loke, PL; Meniconi, M; Monck, NJ; North, CL; Ridgill, MP; Tye, H Heteroaryl inhibitors of PAD4 US Patent US11026937 Publication Date 6/8/2021 More Info.:
Target
Name:
Protein-arginine deiminase type-4
Synonyms:
PAD4 | PADI4 | PADI4_HUMAN | PADI5 | PDI5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
74078.90
Organism:
Homo sapiens (Human)
Description:
gi_216548487
Residue:
663
Sequence:
MAQGTLIRVTPEQPTHAVCVLGTLTQLDICSSAPEDCTSFSINASPGVVVDIAHGPPAKKKSTGSSTWPLDPGVEVTLTMKVASGSTGDQKVQISYYGPKTPPVKALLYLTGVEISLCADITRTGKVKPTRAVKDQRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTLSTKTPKDFFTNHTLVLHVARSEMDKVRVFQATRGKLSSKCSVVLGPKWPSHYLMVPGGKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFRVAPWIMTPNTQPPQEVYACSIFENEDFLKSVTTLAMKAKCKLTICPEEENMDDQWMQDEMEIGYIQAPHKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISGLDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSAQQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQEQQNEGHGEALLFEGIKKKKQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLAESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRCCLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHCGTNVRRKPFSFKWWNMVP
Inhibitor
Name:
BDBM501520
Synonyms:
US11026937, Compound I-96
Type:
Small organic molecule
Emp. Form.:
C23H17N3O2
Mol. Mass.:
367.4
SMILES:
Cc1ccc(cc1)-c1c(C(=O)\C=C\c2cncnc2)c(=O)[nH]c2ccccc12
Structure:
