Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 2 [348-455]
Ligand
BDBM50452554
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry Analysis of Binding to Brd2-BD1 and Brd2-BD2
Kd
300±n/a nM
Citation
 Guy, RK; Slavish, PJ; Shadrick, WR; Young, BM; Boyd, VA; Bharatham, N; Price, JE; Shelat, A Tetrahydroquinoline-based bromodomain inhibitors US Patent  US11028051 Publication Date 6/8/2021 
Target
Name:
Bromodomain-containing protein 2 [348-455]
Synonyms:
BET bromodomain 2(2) (BRD2(2)) | BRD2 | BRD2-BD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (aa 348-455) | KIAA9001 | RING3
Type:
n/a
Mol. Mass.:
12751.52
Organism:
Homo sapiens (Human)
Description:
P25440[348-455]
Residue:
108
Sequence:
EQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPD
  
Inhibitor
Name:
BDBM50452554
Synonyms:
CHEMBL4207106 | US11028051, Cmpd 51
Type:
Small organic molecule
Emp. Form.:
C20H24N2O4
Mol. Mass.:
356.4156
SMILES:
CC(C)OC(=O)N[C@@H]1C[C@H](C)N(C(C)=O)c2ccc(cc12)-c1ccoc1 |r|
Structure:
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