Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM501662
Substrate
n/a
Meas. Tech.
Inhibitory Enzyme Activity (In Vitro Assay)
IC50
5.5±n/a nM
Citation
 Thunuguntla, SSHosahalli, SPanigrahi, SKSchwarz, MArit, M 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors US Patent  US11028054 Publication Date 6/8/2021 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM501662
Synonyms:
US11028054, Example 60
Type:
Small organic molecule
Emp. Form.:
C25H19F4N3O2
Mol. Mass.:
469.4309
SMILES:
Cc1nc2c(cc(cc2[nH]1)-c1c(F)c(F)c(c(F)c1F)-c1cccc(CNC2CC2)c1)C(O)=O
Structure:
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