Reaction Details Report a problem with these data
Target
Glutathione reductase, mitochondrial
Ligand
BDBM501861
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
9890±n/a nM
Citation
 Pelcman, B; Suna, E; Stafford, W; Priede, M Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer US Patent  US11028067 Publication Date 6/8/2021 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM501861
Synonyms:
US11028067, Example 2
Type:
Small organic molecule
Emp. Form.:
C10H6ClN3O4S
Mol. Mass.:
299.69
SMILES:
[O-][N+](=O)c1ccc(Cl)nc1S(=O)(=O)c1ccccn1
Structure:
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