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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502005
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
58.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502005
Synonyms:
US11028083, Example 3a
Type:
Small organic molecule
Emp. Form.:
C22H38N4O
Mol. Mass.:
374.5633
SMILES:
CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@@]2(CC(C)(C)CO2)CC1 |r,wU:15.16,wD:18.26,(8.05,5.22,;6.71,5.99,;5.38,5.22,;4.05,5.99,;2.71,5.22,;2.71,3.68,;1.38,5.99,;.05,5.22,;.6,3.78,;-.6,2.81,;-1,1.33,;-2.54,1.25,;-3.09,2.68,;-1.89,3.65,;-1.49,5.14,;-2.83,5.91,;-4.16,5.14,;-5.49,5.91,;-5.49,7.45,;-5.49,8.99,;-6.96,9.47,;-8.05,10.56,;-6.56,10.95,;-7.86,8.22,;-6.96,6.97,;-4.16,8.22,;-2.83,7.45,)|
Structure:
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