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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502008
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
48.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502008
Synonyms:
US11028083, Example 5a
Type:
Small organic molecule
Emp. Form.:
C22H38F2N4O
Mol. Mass.:
412.5601
SMILES:
CCOCC1(CC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CC(F)(F)Cc12 |r,wU:9.12,(-1.48,5,;-2.81,4.23,;-4.15,5,;-5.48,4.23,;-5.48,2.69,;-6.57,1.6,;-8.06,2,;-5.48,1.15,;-4.15,.38,;-2.81,1.15,;-2.81,2.69,;-4.15,3.46,;-1.48,.38,;.06,.46,;1.39,1.23,;2.72,.46,;2.72,-1.08,;4.06,1.23,;5.39,.46,;6.73,1.23,;8.06,.46,;.61,-.98,;-.59,-1.95,;-.99,-3.43,;-2.52,-3.51,;-2.92,-5,;-4.01,-3.91,;-3.08,-2.08,;-1.88,-1.11,)|
Structure:
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