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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502012
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
50.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502012
Synonyms:
US11028083, Example 8a
Type:
Small organic molecule
Emp. Form.:
C20H36N4O2
Mol. Mass.:
364.5254
SMILES:
CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@](C)(COC)CC1 |r,wU:19.21,16.17,wD:19.22,(7.44,9.22,;6.1,9.99,;4.77,9.22,;3.44,9.99,;2.1,9.22,;2.1,7.68,;.77,9.99,;-.56,9.22,;-.01,7.79,;-1.21,6.82,;-1.29,5.28,;-2.66,4.58,;-3.95,5.42,;-3.87,6.96,;-2.5,7.66,;-2.1,9.14,;-3.44,9.91,;-4.77,9.14,;-6.1,9.91,;-6.1,11.45,;-7.44,10.68,;-6.1,12.99,;-4.77,13.76,;-3.44,12.99,;-4.77,12.22,;-3.44,11.45,)|
Structure:
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