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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502015
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
55.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502015
Synonyms:
US11028083, Example 9b
Type:
Small organic molecule
Emp. Form.:
C27H39N5O2
Mol. Mass.:
465.6309
SMILES:
CNCCN(C)Cc1nn2CCOCc2c1[C@H]1CC[C@@]2(CCN(Cc3ccccc3)C2=O)CC1 |r,wU:19.33,wD:16.17,(7.96,7.45,;6.62,8.22,;5.29,7.45,;3.95,8.22,;2.62,7.45,;2.62,5.91,;1.29,8.22,;-.05,7.45,;.51,6.01,;-.69,5.04,;-.77,3.51,;-2.14,2.81,;-3.44,3.65,;-3.36,5.18,;-1.98,5.88,;-1.58,7.37,;-2.92,8.14,;-2.92,9.68,;-4.25,10.45,;-5.59,9.68,;-7.05,9.2,;-7.96,10.45,;-7.05,11.7,;-7.53,13.16,;-6.5,14.31,;-4.99,13.99,;-3.96,15.13,;-4.43,16.59,;-5.94,16.91,;-6.97,15.77,;-5.59,11.22,;-4.34,12.13,;-5.59,8.14,;-4.25,7.37,)|
Structure:
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