Reaction Details Report a problem with these data
Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502024
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
64.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502024
Synonyms:
N1-((3-(4-(methoxy- methyl)cyclohexyl)- 5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol- 2-yl)methyl)-N1,N2- dimethylethane-1,2- diamine | US11028083, Example 18
Type:
Small organic molecule
Emp. Form.:
C19H34N4O
Mol. Mass.:
334.4995
SMILES:
CNCCN(C)Cc1nn2CCCc2c1C1CCC(COC)CC1 |(8.11,-.78,;6.77,-.01,;5.44,-.78,;4.1,-.01,;2.77,-.78,;2.77,-2.32,;1.44,-.01,;.1,-.78,;.58,-2.24,;-.67,-3.15,;-1.14,-4.61,;-2.68,-4.61,;-3.16,-3.15,;-1.91,-2.24,;-1.44,-.78,;-2.77,-.01,;-4.1,-.78,;-5.44,-.01,;-5.44,1.53,;-6.77,2.3,;-6.77,3.84,;-8.11,4.61,;-4.1,2.3,;-2.77,1.53,)|
Structure:
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