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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502032
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
64.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502032
Synonyms:
8-(2-((Methyl(2- (methylamino)ethyl)- amino)methyl)-5,6- dihydro-4H-pyrrolo- [1,2-b]pyrazol-3-yl)-2- azaspiro[4.5]decan-3- one | US11028083, Example 26
Type:
Small organic molecule
Emp. Form.:
C20H33N5O
Mol. Mass.:
359.5089
SMILES:
CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CNC(=O)C2)CC1 |(8.73,-.98,;7.39,-.21,;6.06,-.98,;4.73,-.21,;3.39,-.98,;3.39,-2.52,;2.06,-.21,;.72,-.98,;1.2,-2.44,;-.05,-3.35,;-.52,-4.81,;-2.06,-4.81,;-2.54,-3.35,;-1.29,-2.44,;-.82,-.98,;-2.15,-.21,;-3.48,-.98,;-4.82,-.21,;-4.82,1.33,;-4.82,2.87,;-6.28,3.35,;-7.19,2.1,;-8.73,2.1,;-6.28,.86,;-3.48,2.1,;-2.15,1.33,)|
Structure:
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