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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502033
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
48.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502033
Synonyms:
2-Benzyl-8-(2- ((methyl(2-(methyl- amino)ethyl)amino)- methyl)-5,6-dihydro- 4H-pyrrolo[1,2-b]- pyrazol-3-yl)-2-aza- spiro[4.5]decan-1-one | US11028083, Example 27
Type:
Small organic molecule
Emp. Form.:
C27H39N5O
Mol. Mass.:
449.6315
SMILES:
CNCCN(C)Cc1nn2CCCc2c1C1CCC2(CCN(Cc3ccccc3)C2=O)CC1 |(7.96,-2.85,;6.62,-2.08,;5.29,-2.85,;3.96,-2.08,;2.62,-2.85,;2.62,-4.39,;1.29,-2.08,;-.05,-2.85,;.43,-4.32,;-.82,-5.22,;-1.29,-6.69,;-2.83,-6.69,;-3.31,-5.22,;-2.06,-4.32,;-1.59,-2.85,;-2.92,-2.08,;-4.25,-2.85,;-5.59,-2.08,;-5.59,-.54,;-7.05,-1.02,;-7.96,.23,;-7.05,1.47,;-7.53,2.94,;-6.5,4.08,;-4.99,3.76,;-3.96,4.9,;-4.44,6.37,;-5.94,6.69,;-6.97,5.54,;-5.59,1,;-4.34,1.9,;-4.25,.23,;-2.92,-.54,)|
Structure:
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