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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502047
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
98.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502047
Synonyms:
2-(2-Methoxyethyl)-8- (2-((methyl(2-(methyl- amino)ethyl)amino)- methyl)-6,7-dihydro- 4H-pyrazolo[5,1-c]- [1,4]oxazin-3-yl)-2- azapsiro[4.5]decan-1- one | US11028083, Example 41
Type:
Small organic molecule
Emp. Form.:
C23H39N5O3
Mol. Mass.:
433.5875
SMILES:
CNCCN(C)Cc1nn2CCOCc2c1C1CCC2(CCN(CCOC)C2=O)CC1 |(7.96,-2.51,;6.62,-1.74,;5.29,-2.51,;3.96,-1.74,;2.62,-2.51,;2.62,-4.05,;1.29,-1.74,;-.05,-2.51,;.43,-3.97,;-.82,-4.88,;-.98,-6.41,;-2.38,-7.04,;-3.63,-6.13,;-3.47,-4.6,;-2.06,-3.97,;-1.59,-2.51,;-2.92,-1.74,;-4.25,-2.51,;-5.59,-1.74,;-5.59,-.2,;-7.05,-.67,;-7.96,.57,;-7.05,1.82,;-7.53,3.28,;-6.5,4.43,;-6.97,5.89,;-5.94,7.04,;-5.59,1.34,;-4.34,2.25,;-4.25,.57,;-2.92,-.2,)|
Structure:
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