Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502065
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
362±n/a nM
Citation
 Di Francesco, MEJones, PMcAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502065
Synonyms:
(3-(4,4-bis(Ethoxy- methyl)cyclohexyl)-2- ((methyl(2-(methyl- amino)ethyl)amino)- methyl)-5,6-dihydro- 4H-pyrrolo[1,2-b]- pyrazol-6-yl)methanol | US11028083, Example 59
Type:
Small organic molecule
Emp. Form.:
C24H44N4O3
Mol. Mass.:
436.6312
SMILES:
CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2C(CO)CCc12
Structure:
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