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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502066
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
148±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502066
Synonyms:
1-(3-(4,4-bis(Ethoxy- methyl)cyclohexyl)-2- ((methyl(2-(methyl- amino)ethyl)amino) methyl)-6,7-dihydro- pyrazolo[1,5-a]- pyrazin-5(4H)-yl)- propan-1-one | US11028083, Example 60
Type:
Small organic molecule
Emp. Form.:
C26H47N5O3
Mol. Mass.:
477.6831
SMILES:
CCOCC1(COCC)CCC(CC1)c1c(CN(C)CCNC)nn2CCN(Cc12)C(=O)CC
Structure:
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