Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502069
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
70.0±n/a nM
Citation
 Di Francesco, MEJones, PMcAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502069
Synonyms:
US11028083, Example 62b
Type:
Small organic molecule
Emp. Form.:
C19H34N4O2S
Mol. Mass.:
382.564
SMILES:
CCS(=O)(=O)C1CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12 |r,wD:8.11,(-8.5,-3.52,;-8.03,-2.06,;-6.52,-1.74,;-6.84,-.23,;-6.2,-3.24,;-5.01,-1.42,;-4.54,.05,;-3.03,.37,;-2,-.78,;-2.48,-2.24,;-3.98,-2.56,;-.49,-.46,;.13,.95,;-.64,2.28,;.13,3.62,;-.64,4.95,;1.67,3.62,;2.44,2.28,;3.98,2.28,;4.75,.95,;1.66,.79,;1.98,-.72,;3.13,-1.75,;2.5,-3.15,;.97,-2.99,;.65,-1.49,)|
Structure:
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