Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502081
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
434±n/a nM
Citation
 Di Francesco, MEJones, PMcAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502081
Synonyms:
US11028083, Example 68b
Type:
Small organic molecule
Emp. Form.:
C20H33N5O
Mol. Mass.:
359.5089
SMILES:
CNCCN(C)Cc1nn2CCCc2c1[C@H]1CCC2(CCC(=O)N2)CC1 |r,wD:15.16,(7.96,-.98,;6.62,-.21,;5.29,-.98,;3.96,-.21,;2.62,-.98,;2.62,-2.52,;1.29,-.21,;-.05,-.98,;.43,-2.44,;-.82,-3.35,;-1.29,-4.81,;-2.83,-4.81,;-3.31,-3.35,;-2.06,-2.44,;-1.59,-.98,;-2.92,-.21,;-2.92,1.33,;-4.25,2.1,;-5.59,1.33,;-7.05,.86,;-7.96,2.1,;-7.05,3.35,;-7.53,4.81,;-5.59,2.87,;-5.59,-.21,;-4.25,-.98,)|
Structure:
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