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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502103
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
36.0±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502103
Synonyms:
US11028083, Example 79b | US11028083, Example 80b
Type:
Small organic molecule
Emp. Form.:
C21H34F2N4O
Mol. Mass.:
396.5177
SMILES:
CNCCN(C)Cc1nn2CC(F)(F)Cc2c1[C@H]1CC[C@@]2(CCCOC2)CC1 |r,wD:20.28,17.18,(8.1,8.22,;6.77,8.99,;5.44,8.22,;4.1,8.99,;2.77,8.22,;2.77,6.68,;1.44,8.99,;.1,8.22,;.65,6.78,;-.54,5.82,;-.94,4.33,;-2.48,4.25,;-2.48,2.71,;-3.81,3.48,;-3.03,5.69,;-1.83,6.65,;-1.44,8.14,;-2.77,8.91,;-2.77,10.45,;-4.1,11.22,;-5.44,10.45,;-5.44,11.99,;-6.77,12.76,;-8.1,11.99,;-8.1,10.45,;-6.77,9.68,;-5.44,8.91,;-4.1,8.14,)|
Structure:
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