Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502127
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
27.0±n/a nM
Citation
 Di Francesco, MEJones, PMcAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502127
Synonyms:
US11028083, Example 94b
Type:
Small organic molecule
Emp. Form.:
C22H40N4O
Mol. Mass.:
376.5792
SMILES:
CCOC[C@]1(CC)CC[C@@H](CC1)c1c(CN(C)CCNC)nn2CCCc12 |r,wU:4.4,wD:4.3,9.12,(-2.1,4.26,;-3.44,3.49,;-4.77,4.26,;-6.1,3.49,;-6.1,1.95,;-7.44,1.18,;-7.44,-.36,;-4.77,2.72,;-3.44,1.95,;-3.44,.41,;-4.77,-.36,;-6.1,.41,;-2.1,-.36,;-.56,-.28,;.77,.49,;2.1,-.28,;2.1,-1.82,;3.44,.49,;4.77,-.28,;6.1,.49,;7.44,-.28,;-.01,-1.72,;-1.21,-2.69,;-1.61,-4.18,;-3.15,-4.26,;-3.7,-2.82,;-2.5,-1.85,)|
Structure:
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