Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502128
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
30.0±n/a nM
Citation
 Di Francesco, MEJones, PMcAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502128
Synonyms:
US11028083, Example 95a
Type:
Small organic molecule
Emp. Form.:
C21H36N4O
Mol. Mass.:
360.5367
SMILES:
CNCCN(C)Cc1nn2CCCc2c1[C@H]1CC[C@]2(CCCOC2)CC1 |r,wU:18.25,15.16,(4.1,-4.58,;5.44,-3.81,;5.44,-2.27,;4.1,-1.5,;4.1,.04,;5.44,.81,;2.77,.81,;1.44,.04,;1.99,-1.4,;.79,-2.37,;.39,-3.85,;-1.15,-3.93,;-1.7,-2.5,;-.5,-1.53,;-.1,-.04,;-1.44,.73,;-2.77,-.04,;-4.1,.73,;-4.1,2.27,;-4.1,3.81,;-5.44,4.58,;-6.77,3.81,;-6.77,2.27,;-5.44,1.5,;-2.77,3.04,;-1.44,2.27,)|
Structure:
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