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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM502141
Substrate
n/a
Meas. Tech.
PRMT1 Enzymatic Assay
IC50
128±n/a nM
Citation
 Di Francesco, ME; Jones, P; McAfoos, TJ Ethanediamine-heterocycle derivatives as inhibitors of protein arginine methyltransferases US Patent  US11028083 Publication Date 6/8/2021 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | ANM1_HUMAN | HMT2 | HRMT1L2 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | IR1B4 | Interferon receptor 1-bound protein 4 | PRMT1 | Protein arginine N-methyltransferase 1 | Protein-arginine N-methyltransferase 1 | Synonyms=HMT2
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Homo sapiens
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM502141
Synonyms:
N1-((3-(4,4-bis((2,2,2- trifluoroethoxy)methyl)- cyclohexyl)-5,5-difluoro-5,6- dihydro-4H-pyrrolo[1,2-b]- pyrazol-2-yl)methyl)-N1,N2- dimethylethane-1,2-diamine | US11028083, Example 102
Type:
Small organic molecule
Emp. Form.:
C23H34F8N4O2
Mol. Mass.:
550.5289
SMILES:
CNCCN(C)Cc1nn2CC(F)(F)Cc2c1C1CCC(COCC(F)(F)F)(COCC(F)(F)F)CC1
Structure:
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