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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503317
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
12000±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503317
Synonyms:
6-Amino-2-(4-amino-4-methyl- piperidin-1-yl)-5-(2,3-dichloro- phenyl)-pyrimidine-4-carboxylic- acid-(2-hydroxy-ethyl)-amide | US11033547, Compound 17 | US11696916, Compound 17
Type:
Small organic molecule
Emp. Form.:
C19H24Cl2N6O2
Mol. Mass.:
439.339
SMILES:
CC1(N)CCN(CC1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(=O)NCCO |(1.58,-6.7,;2.67,-5.62,;3.76,-6.7,;1.33,-4.85,;1.33,-3.31,;2.67,-2.54,;4,-3.31,;4,-4.85,;2.67,-1,;4,-.23,;4,1.31,;5.33,2.08,;2.67,2.08,;2.67,3.62,;1.33,4.39,;1.33,5.93,;2.67,6.7,;4,5.93,;5.33,6.7,;4,4.39,;5.33,3.62,;1.33,1.31,;1.33,-.23,;,2.08,;,3.62,;-1.33,1.31,;-2.67,2.08,;-4,1.31,;-5.33,2.08,)|
Structure:
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