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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503318
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
104±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503318
Synonyms:
2-(4-Amino-4-methyl-piperidin-1- yl)-5-(2,3-dichlorophenyl)-6-methyl- pyrimidine-4-carboxylic acid amide | US11033547, Compound 18
Type:
Small organic molecule
Emp. Form.:
C18H21Cl2N5O
Mol. Mass.:
394.298
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC(C)(N)CC1 |(3.33,2.08,;2,1.31,;2,-.23,;.67,-1,;-.67,-.23,;-.67,1.31,;-2,2.08,;-3.33,1.31,;-2,3.62,;.67,2.08,;.67,3.62,;-.67,4.39,;-.67,5.93,;.67,6.7,;2,5.93,;3.33,6.7,;2,4.39,;3.33,3.62,;.67,-2.54,;-.67,-3.31,;-.67,-4.85,;.67,-5.62,;-.42,-6.7,;1.76,-6.7,;2,-4.85,;2,-3.31,)|
Structure:
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