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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503326
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
82.0±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503326
Synonyms:
(4M)-6-amino-2-(4-amino-4- methylpiperidin-1-yl)-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide | US11033547, Compound 26 | US11033547, Compound 27 | US11696916, Compound 27
Type:
Small organic molecule
Emp. Form.:
C17H20Cl2N6O
Mol. Mass.:
395.286
SMILES:
CC1(N)CCN(CC1)c1nc(N)c(c(n1)C(N)=O)-c1cccc(Cl)c1Cl |(6.05,-3.18,;5.28,-1.85,;6.62,-1.08,;4.19,-2.94,;2.71,-2.54,;2.31,-1.05,;3.4,.04,;4.88,-.36,;.82,-.65,;.42,.84,;-1.07,1.23,;-1.46,2.72,;-2.15,.15,;-1.76,-1.34,;-.27,-1.74,;-2.84,-2.43,;-2.45,-3.92,;-4.33,-2.03,;-3.64,.54,;-4.73,-.54,;-6.22,-.15,;-6.62,1.34,;-5.53,2.43,;-5.93,3.92,;-4.04,2.03,;-3.64,3.52,)|
Structure:
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