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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503329
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
260±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503329
Synonyms:
6-amino-2-[4-amino-4- (hydroxymethyl)piperidin-1-yl]-5- (2,3-dichlorophenyl)-pyrimidine-4- carboxamide | US11033547, Compound 29 | US11696916, Compound 29
Type:
Small organic molecule
Emp. Form.:
C17H20Cl2N6O2
Mol. Mass.:
411.286
SMILES:
NC(=O)c1nc(nc(N)c1-c1cccc(Cl)c1Cl)N1CCC(N)(CO)CC1 |(-3.82,-3.57,;-3.82,-2.03,;-5.16,-1.26,;-2.49,-1.26,;-1.15,-2.03,;.18,-1.26,;.18,.28,;-1.15,1.05,;-1.15,2.59,;-2.49,.28,;-3.82,1.05,;-5.16,.28,;-6.49,1.05,;-6.49,2.59,;-5.16,3.36,;-5.16,4.9,;-3.82,2.59,;-2.49,3.36,;1.51,-2.03,;1.51,-3.57,;2.85,-4.34,;4.18,-3.57,;4.95,-4.9,;5.72,-3.57,;6.49,-2.23,;4.18,-2.03,;2.85,-1.26,)|
Structure:
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