Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503333
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
2400±n/a nM
Citation
 Jorand-LeBrun, CBoivin, RMochalkin, IJohnson, TLinde, NMusch, DKumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503333
Synonyms:
2-(7-Amino-3-oxa-9-aza- bicyclo[3.3.1]non-9-yl)-5-(2,3- dichlorophenyl)-6-methyl- pyrimidine-4-carboxylic acid amide | US11033547, Compound 33 | US11696916, Compound 33
Type:
Small organic molecule
Emp. Form.:
C19H21Cl2N5O2
Mol. Mass.:
422.308
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1C2COCC1CC(N)C2 |(-2.6,3.21,;-1.83,1.88,;-.29,1.88,;.48,.54,;-.29,-.79,;-1.83,-.79,;-2.6,-2.12,;-1.51,-3.21,;-4.14,-2.12,;-2.6,.54,;-4.14,.54,;-4.91,-.79,;-6.45,-.79,;-7.22,.54,;-6.45,1.88,;-7.22,3.21,;-4.91,1.88,;-4.14,3.21,;2.02,.54,;3.39,1.9,;4.34,1.31,;4.5,.08,;3.99,-.94,;2.83,-1.31,;4.7,-1.7,;5.69,-.26,;7.22,-.48,;5.25,1.44,)|
Structure:
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