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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503337
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1100±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503337
Synonyms:
2-((S)-6-Amino-2-aza- spiro[4.4]non-2-yl)-5-(2,3-dichloro- phenyl)-6-methyl-pyrimidine-4- carboxylic acid amide | US11033547, Compound 37 | US11696916, Compound 37
Type:
Small organic molecule
Emp. Form.:
C20H23Cl2N5O
Mol. Mass.:
420.336
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(CCC[C@@H]2N)C1 |r,wD:25.28,(-2.37,3.21,;-1.6,1.88,;-.06,1.88,;.71,.54,;-.06,-.79,;-1.6,-.79,;-2.37,-2.12,;-1.28,-3.21,;-3.91,-2.12,;-2.37,.54,;-3.91,.54,;-4.68,-.79,;-6.22,-.79,;-6.99,.54,;-6.22,1.88,;-6.99,3.21,;-4.68,1.88,;-3.91,3.21,;2.25,.54,;2.25,-1,;3.71,-1.47,;4.62,-.23,;5.53,1.02,;6.99,.54,;6.99,-1,;5.53,-1.47,;5.05,-2.94,;3.71,1.02,)|
Structure:
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