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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503341
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
310±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503341
Synonyms:
6-amino-2-[4-(aminomethyl)-4- methylpiperidin-1-yl]-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide | US11033547, Compound 41 | US11696916, Compound 41
Type:
Small organic molecule
Emp. Form.:
C18H22Cl2N6O
Mol. Mass.:
409.313
SMILES:
CC1(CN)CCN(CC1)c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |(4.58,-4.98,;4.18,-3.49,;5.72,-3.49,;6.49,-2.16,;4.18,-1.95,;2.85,-1.18,;1.51,-1.95,;1.51,-3.49,;2.85,-4.26,;.18,-1.18,;.18,.36,;-1.15,1.13,;-1.15,2.67,;-2.49,.36,;-3.82,1.13,;-5.16,.36,;-6.49,1.13,;-6.49,2.67,;-5.16,3.44,;-5.16,4.98,;-3.82,2.67,;-2.49,3.44,;-2.49,-1.18,;-1.15,-1.95,;-3.82,-1.95,;-3.82,-3.49,;-5.16,-1.18,)|
Structure:
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