Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503358
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
4400±n/a nM
Citation
 Jorand-LeBrun, CBoivin, RMochalkin, IJohnson, TLinde, NMusch, DKumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503358
Synonyms:
2-(1-Amino-5-aza-spiro[2.4]hept-5- yl)-5-(2,3-dichloro-phenyl)-6- methyl-pyrimidine-4-carboxylic acid amide | US11033547, Compound 58 | US11696916, Compound 58
Type:
Small organic molecule
Emp. Form.:
C18H19Cl2N5O
Mol. Mass.:
392.282
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(CC2N)C1 |(-2.65,-3.33,;-1.88,-2,;-.34,-2,;.43,-.67,;-.34,.67,;-1.88,.67,;-2.65,2,;-1.88,3.33,;-4.19,2,;-2.65,-.67,;-4.19,-.67,;-4.96,.67,;-6.5,.67,;-7.27,-.67,;-6.5,-2,;-7.27,-3.33,;-4.96,-2,;-4.19,-3.33,;1.97,-.67,;2.87,.58,;4.34,.1,;4.34,-1.44,;4.96,-2.84,;5.87,-1.6,;7.27,-.97,;2.87,-1.91,)|
Structure:
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