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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503369
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1300±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503369
Synonyms:
6-amino-2-[2-(aminomethyl)- azetidin-1-yl]-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide | US11033547, Compound 71 | US11696916, Compound 71
Type:
Small organic molecule
Emp. Form.:
C15H16Cl2N6O
Mol. Mass.:
367.233
SMILES:
NCC1CCN1c1nc(N)c(-c2cccc(Cl)c2Cl)c(n1)C(N)=O |(5.9,-.96,;4.36,-.96,;3.59,-2.3,;3.99,-3.78,;2.5,-4.18,;2.1,-2.69,;.77,-1.93,;.77,-.38,;-.57,.38,;-.57,1.93,;-1.9,-.38,;-3.23,.38,;-4.57,-.38,;-5.9,.38,;-5.9,1.93,;-4.57,2.69,;-4.57,4.23,;-3.23,1.93,;-1.9,2.69,;-1.9,-1.93,;-.57,-2.69,;-3.23,-2.69,;-3.23,-4.23,;-4.57,-1.93,)|
Structure:
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