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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503389
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
100.0±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503389
Synonyms:
6-Amino-2-(4-amino-4-methyl- azepan-1-yl)-5-(2,3-dichloro- phenyl)-pyrimidine-4-carboxylic acid amide | US11033547, Compound 91 | US11696916, Compound 91
Type:
Small organic molecule
Emp. Form.:
C18H22Cl2N6O
Mol. Mass.:
409.313
SMILES:
CC1(N)CCCN(CC1)c1nc(N)c(c(n1)C(N)=O)-c1cccc(Cl)c1Cl |(5.17,-5.01,;4.76,-3.53,;6.3,-3.52,;5.16,-2.04,;4.24,-.8,;2.7,-.75,;1.7,-1.92,;1.99,-3.43,;3.35,-4.15,;.36,-1.15,;.36,.39,;-.97,1.16,;-.97,2.7,;-2.3,.39,;-2.3,-1.15,;-.97,-1.92,;-3.39,-2.24,;-2.8,-3.66,;-4.93,-2.24,;-3.64,1.16,;-4.97,.39,;-6.3,1.16,;-6.3,2.7,;-4.97,3.47,;-4.97,5.01,;-3.64,2.7,;-2.3,3.47,)|
Structure:
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