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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM503408
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
530±n/a nM
Citation
 Jorand-LeBrun, C; Boivin, R; Mochalkin, I; Johnson, T; Linde, N; Musch, D; Kumar, D Carboxamide-pyrimidine derivatives as SHP2 antagonists US Patent  US11033547 Publication Date 6/15/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM503408
Synonyms:
2-(4-Amino-4-methyl-piperidin-1- yl)-5-(2-chloro-3-trifluoromethyl- phenyl)-6-methyl-pyrimidine-4- carboxylic acid amide | US11033547, Compound 111 | US11696916, Compound 111
Type:
Small organic molecule
Emp. Form.:
C19H21ClF3N5O
Mol. Mass.:
427.851
SMILES:
Cc1nc(nc(C(N)=O)c1-c1cccc(c1Cl)C(F)(F)F)N1CCC(C)(N)CC1 |(2.55,1.46,;1.21,.69,;1.21,-.85,;-.12,-1.62,;-1.46,-.85,;-1.46,.69,;-2.79,1.46,;-3.88,.37,;-2.79,3,;-.12,1.46,;-.12,3,;-1.46,3.77,;-1.46,5.31,;-.12,6.08,;1.21,5.31,;1.21,3.77,;2.55,3,;2.55,6.08,;3.63,4.99,;2.15,7.57,;3.88,6.85,;-.12,-3.16,;1.21,-3.93,;1.21,-5.47,;-.12,-6.24,;-1.21,-7.33,;.65,-7.57,;-1.46,-5.47,;-1.46,-3.93,)|
Structure:
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