Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM276751
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
200±n/a nM
Citation
 Boehm, MCabral, SDowling, MSFutatsugi, KHuard, KLee, ECLondregan, ATPolivkova, JPrice, DALi, Q Diacylglycerol acyl transferase 2 inhibitors US Patent  US11034678 Publication Date 6/15/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM276751
Synonyms:
(R)-2-(5-((3-Ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-(tetrahydrofuran-3-yl)pyrimidine-5-carboxamide | US10071992, Example 2 | US10071992, Example 3.7 | US11034678, Example 2 | US11065249, WO2018033832-Ex.-2 | WO2018033832, Ex. 2
Type:
Small organic molecule
Emp. Form.:
C21H21N5O4
Mol. Mass.:
407.4225
SMILES:
CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@@H]1CCOC1 |r|
Structure:
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