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TargetDiacylglycerol O-acyltransferase 2
LigandBDBM276754
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
IC50 196±n/a nM
Citation Boehm, MCabral, SDowling, MSFutatsugi, KHuard, KLee, ECLondregan, ATPolivkova, JPrice, DALi, Q Diacylglycerol acyl transferase 2 inhibitors US Patent US11034678 Publication Date 6/15/2021
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 2
Name:Diacylglycerol O-acyltransferase 2
Synonyms:ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:Multi-pass membrane protein
Mol. Mass.:43848.90
Organism:Homo sapiens (Human)
Description:Q96PD7
Residue:388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLN
RSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKG
GRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATE
VSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGG
AAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQ
KKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHT
MYMEALVKLFDKHKTKFGLPETEVLEVN
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BDBM276754
NameBDBM276754
Synonyms:N-(1,1-dioxidotetrahydro- thiophen-3-yl)-2-(5-((3- ethoxypyridin-2-yl)oxy) pyridin-3-yl)pyrimidine- 5-carboxamide | US10071992, Example 3.3 | US11034678, Example 3.3 | US11065249, WO2018033832-Ex.-3.3
TypeSmall organic molecule
Emp. Form.C21H21N5O5S
Mol. Mass.455.487
SMILESCCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)NC1CCS(=O)(=O)C1
Structure
n/a