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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM276763
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
3.70±n/a nM
Citation
 Boehm, M; Cabral, S; Dowling, MS; Futatsugi, K; Huard, K; Lee, EC; Londregan, AT; Polivkova, J; Price, DA; Li, Q Diacylglycerol acyl transferase 2 inhibitors US Patent  US11034678 Publication Date 6/15/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM276763
Synonyms:
US10071992, Example 8 | US11034678, Example 8 | US11065249, WO2018033832-Ex.-8 | WO2018033832, Ex. 8
Type:
Small organic molecule
Emp. Form.:
C21H20FN5O4
Mol. Mass.:
425.413
SMILES:
CCOc1cc(F)cnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CCOC1 |r|
Structure:
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