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Target
Sphingosine 1-phosphate receptor 3
Ligand
BDBM399260
Substrate
n/a
Meas. Tech.
Competition Binding Assay
IC50
38.0±n/a nM
Citation
 Roberts, E; Rosen, H; Urbano, M; Guerrero, M Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders US Patent  US11034691 Publication Date 6/15/2021 
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
  
Inhibitor
Name:
BDBM399260
Synonyms:
US10323029, Generic formula 52560 IB | US11034691, CYM generic formula 52560 IB
Type:
Small organic molecule
Emp. Form.:
C21H15Cl2N3O
Mol. Mass.:
396.269
SMILES:
Cc1cc(ccc1C#N)C(=O)N[C@@H](c1ccc(Cl)cc1)c1ccc(Cl)cn1 |r|
Structure:
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