Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM503932
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.154±n/a nM
Citation
 Chan, BDaniels, BDrobnick, JGazzard, LHeffron, THuestis, MLiang, JMalhotra, SMendonca, RRajapaksa, NSiu, MStivala, CTellis, JWang, WWei, BZhou, ACartwright, MWGancia, EJones, GLainchbury, MMadin, ASeward, EFavor, DFong, KCGood, AHu, YHu, BLu, A Naphthyridines as inhibitors of HPK1 US Patent  US11034692 Publication Date 6/15/2021 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM503932
Synonyms:
US11034692, Compound 211 | cis-N-(8-amino-6-(2,3-dihydro-1H- pyrrolo[2,3-c]pyridin-4-yl)-2,7- naphthyridin-3-yl)-2- fluorocyclopropanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C19H17FN6O
Mol. Mass.:
364.3763
SMILES:
Nc1nc(cc2cc(NC(=O)[C@@H]3C[C@@H]3F)ncc12)-c1cncc2NCCc12 |r|
Structure:
Search PDB for entries with ligand similarity: