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Target
Nuclear receptor ROR-gamma
Ligand
BDBM504182
Substrate
n/a
Meas. Tech.
Transcreener-Fluorecescence Polarization Assay
Ki
17.0±n/a nM
Citation
 Bryan, MC; Do, S; Drobnick, J; Gobbi, A; Katsumoto, T; Kiefer, Jr., JR; Liang, J; Rajapaksa, NS; Chen, Y; Fu, L; Lai, KW; Liu, Z; Wai, J; Wang, F Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators US Patent  US11034698 Publication Date 6/15/2021 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM504182
Synonyms:
N-(6-(((3S,4S)-4-Amino-1-(2-amino-2-oxoethyl)pyrrolidin-3-yl)oxy)-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide and N-(6-(((3R,4R)-4-Amino-1-(2-amino-2-oxoethyl)pyrrolidin-3-yl)oxy)-2,2-dimethyl-2,3-dihydrobenzofuran-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | US11034698, Example 19 | US11034698, Example 20
Type:
Small organic molecule
Emp. Form.:
C23H27N7O4
Mol. Mass.:
465.505
SMILES:
CC1(C)Cc2cc(NC(=O)c3cnn4cccnc34)c(O[C@H]3CN(CC(N)=O)C[C@@H]3N)cc2O1 |r|
Structure:
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