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TargetMetabotropic glutamate receptor 4
LigandBDBM504285
Substrate/Competitorn/a
Meas. Tech.Biological Assay
EC50 114±n/a nM
Citation Biemans, BGuba, WJaeschke, GLindemann, LO''Hara, FRicci, ARueher, DVieira, E Ethynyl derivatives US Patent US11034699 Publication Date 6/15/2021
More Info.:Get all data from this article,  Assay Method
 
Metabotropic glutamate receptor 4
Name:Metabotropic glutamate receptor 4
Synonyms:GRM4 | Glutamate receptor, metabotropic 4 | Metabotropic glutamate receptor 4 | mGluR4 | metabotropic glutamate 4
Type:Protein
Mol. Mass.:101899.95
Organism:Homo sapiens (Human)
Description:Q14833
Residue:912
Sequence:
MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGR
GSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSL
TFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYA
STAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQ
KSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRA
NQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNI
WFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHAL
HAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQY
QLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCW
HCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIA
ATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLG
LGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVV
DPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPET
FNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMP
KVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALAT
KQTYVTYTNHAI
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  Blast E-value cutoff:
BDBM504285
NameBDBM504285
Synonyms:(8S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-1′-ethyl-spiro[6,7-dihydro-5H-isoquinoline-8,6′-hexahydropyrimidine]-2′,4′-dione | US11034699, Example 11
TypeSmall organic molecule
Emp. Form.C28H23F2N3O2
Mol. Mass.471.4979
SMILESCCN1C(=O)N(C(=O)C[C@]11CCCc2ccncc12)c1c(F)cc(cc1F)C#Cc1ccccc1 |r|
Structure
n/a