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Target
RNA-binding protein FXR1
Ligand
BDBM504303
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
EC50
264±16 nM
Citation
 Pellicciari, R; Gioiello, A Farnesoid X receptor modulators US Patent  US11034717 Publication Date 6/15/2021 
Target
Name:
RNA-binding protein FXR1
Synonyms:
FXR1 | FXR1_HUMAN | Fragile X mental retardation syndrome-related protein 1 | hFXR1p
Type:
Protein
Mol. Mass.:
69715.95
Organism:
Human
Description:
P51114
Residue:
621
Sequence:
MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS
  
Inhibitor
Name:
BDBM504303
Synonyms:
3α,7α,11β-trihydroxy-6α-ethyl-5β-cholan-24-ol | US11034717, Compound 4
Type:
Small organic molecule
Emp. Form.:
C26H46O4
Mol. Mass.:
422.641
SMILES:
CC[C@H]1[C@@H](O)C2C3CC[C@H]([C@H](C)CCCO)[C@@]3(C)C[C@H](O)C2[C@@]2(C)CC[C@@H](O)C[C@@H]12 |r|
Structure:
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