Target
RNA-binding protein FXR1
Ligand
BDBM504305
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
EC50
200±18 nM
Citation
 Pellicciari, RGioiello, A Farnesoid X receptor modulators US Patent  US11034717 Publication Date 6/15/2021
Target
Name:
RNA-binding protein FXR1
Synonyms:
Fragile X mental retardation syndrome-related protein 1 | hFXR1p
Type:
Protein
Mol. Mass.:
69715.95
Organism:
Human
Description:
P51114
Residue:
621
Sequence:
MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINTLKEENTQEAAVLNGVS
  
Inhibitor
Name:
BDBM504305
Synonyms:
US11034717, Compound A
Type:
Small organic molecule
Emp. Form.:
C26H44O4
Mol. Mass.:
420.6252
SMILES:
CC[C@H]1[C@@H](O)C2C3CC[C@H]([C@H](C)CCC(O)=O)[C@@]3(C)CCC2[C@@]2(C)CC[C@@H](O)C[C@@H]12 |r|
Structure:
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