Target
RNA-binding protein FXR1
Ligand
BDBM504310
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
EC50
270±20 nM
Citation
 Pellicciari, RGioiello, A Farnesoid X receptor modulators US Patent  US11034717 Publication Date 6/15/2021
Target
Name:
RNA-binding protein FXR1
Synonyms:
Fragile X mental retardation syndrome-related protein 1 | mFxr1p
Type:
Protein
Mol. Mass.:
76224.09
Organism:
Mouse
Description:
Q61584
Residue:
677
Sequence:
MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEISEGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSNIQQARKVPGVTAIELDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGMGFRPSSTRGPEREKGYATDESTVSSVQGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRETRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGLTESDTASVNENGLDDSEKKPQRRNRSRRRRFRGQAEDRQPVTVADYISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDEIPKLPRTLGEEKTKTLKEDSTQEAAVLNGVS
  
Inhibitor
Name:
BDBM504310
Synonyms:
3α,7α,11β-trihydroxy-6α-ethyl-22-(1,2,4-oxadiazol-5-oxo-3-yl)-23,24-bisnor-5β-cholane | US11034717, Compound 6
Type:
Small organic molecule
Emp. Form.:
C26H42N2O5
Mol. Mass.:
462.6221
SMILES:
CC[C@H]1[C@@H](O)C2C3CC[C@H]([C@H](C)Cc4nc(=O)o[nH]4)[C@@]3(C)C[C@H](O)C2[C@@]2(C)CC[C@@H](O)C[C@@H]12 |r|
Structure:
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