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TargetFragile X mental retardation syndrome-related protein 1
LigandBDBM504311
Substrate/Competitorn/a
Meas. Tech.AlphaScreen Assay
EC50 210±10 nM
Citation Pellicciari, RGioiello, A Farnesoid X receptor modulators US Patent US11034717 Publication Date 6/15/2021
More Info.:Get all data from this article,  Assay Method
 
Fragile X mental retardation syndrome-related protein 1
Name:Fragile X mental retardation syndrome-related protein 1
Synonyms:mFxr1p
Type:Protein
Mol. Mass.:76224.09
Organism:Mouse
Description:Q61584
Residue:677
Sequence:
MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEIS
EGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKT
VKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKR
VNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSN
IQQARKVPGVTAIELDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNLVGKVIGKN
GKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKE
VEQLRMERLQIDEQLRQIGMGFRPSSTRGPEREKGYATDESTVSSVQGSRSYSGRGRGRR
GPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRETRHQRDSRRRPGGRGRSVSG
GRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQTADTDASESHHSTNRRRRSRRRRT
DEDAVLMDGLTESDTASVNENGLDDSEKKPQRRNRSRRRRFRGQAEDRQPVTVADYISRA
ESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDEIPKLPRTLGEEKTK
TLKEDSTQEAAVLNGVS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM504311
NameBDBM504311
Synonyms:3α,7α,11β-trihydroxy-6α-ethyl-23-(1,2,4-oxadiazol-5-oxo-3-yl)-23-nor-5β-cholane | US11034717, Compound 7
TypeSmall organic molecule
Emp. Form.C27H44N2O5
Mol. Mass.476.6487
SMILESCC[C@H]1[C@@H](O)C2C3CC[C@H]([C@H](C)CCc4nc(=O)o[nH]4)[C@@]3(C)C[C@H](O)C2[C@@]2(C)CC[C@@H](O)C[C@@H]12 |r|
Structure
n/a