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Target
Sentrin-specific protease/Small ubiquitin-related modifier 2
Ligand
BDBM103834
Substrate
n/a
Meas. Tech.
Enzyme Kinetic Assay
IC50
26600±2500 nM
Citation
 Chen, Y; Chen, C; Namanja, A Methods of identifying SENP1 inhibitors US Patent  US11041859 Publication Date 6/22/2021 
Target
Name:
Sentrin-specific protease/Small ubiquitin-related modifier 2
Synonyms:
SUMO2/SENP2
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Small ubiquitin-related modifier 2
Synonyms:
SMT3B | SMT3H2 | SUMO2 | SUMO2_HUMAN | Small ubiquitin-related modifier 2
Type:
Protein
Mol. Mass.:
10869.09
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
95
Sequence:
MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
  
Component 2
Name:
Sentrin-specific protease 2
Synonyms:
KIAA1331 | SENP2 | SENP2_HUMAN | Sentrin-specific protease 2 (SENP2)
Type:
Protein
Mol. Mass.:
67890.62
Organism:
Homo sapiens (Human)
Description:
Q9HC62
Residue:
589
Sequence:
MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
  
Inhibitor
Name:
BDBM103834
Synonyms:
SPI-09 | US11041859, Code SPI-09 | US9791447, Compound SPI-09
Type:
Small organic molecule
Emp. Form.:
C16H13N3O9S3
Mol. Mass.:
487.484
SMILES:
Nc1ccc2cc(cc(c2c1\N=N\c1ccc(cc1)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
Structure:
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