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Target
Sentrin-specific protease 7
Ligand
BDBM103833
Substrate
n/a
Meas. Tech.
Enzyme Kinetic Assay
IC50
2800±1600 nM
Citation
 Chen, Y; Chen, C; Namanja, A Methods of identifying SENP1 inhibitors US Patent  US11041859 Publication Date 6/22/2021 
Target
Name:
Sentrin-specific protease 7
Synonyms:
KIAA1707 | SENP7 | SENP7_HUMAN | SSP2 | SUSP2 | Sentrin-specific protease 7 (SENP7)
Type:
Protein
Mol. Mass.:
119657.39
Organism:
Homo sapiens (Human)
Description:
Q9BQF6
Residue:
1050
Sequence:
MDKRKLGRRPSSSEIITEGKRKKSSSDLSEIRKMLNAKPEDVHVQSPLSKFRSSERWTLPLQWERSLRNKVISLDHKNKKHIRGCPVTSKSSPERQLKVMLTNVLWTDLGRKFRKTLPRNDANLCDANKVQSDSLPSTSVDSLETCQKLEPLRQSLNLSERIPRVILTNVLGTELGRKYIRTPPVTEGSLSDTDNLQSEQLSSSSDGSLESYQNLNPHKSCYLSERGSQRSKTVDDNSAKQTAHNKEKRRKDDGISLLISDTQPEDLNSGSRGCDHLEQESRNKDVKYSDSKVELTLISRKTKRRLRNNLPDSQYCTSLDKSTEQTKKQEDDSTISTEFEKPSENYHQDPKLPEEITTKPTKSDFTKLSSLNSQELTLSNATKSASAGSTTETVENSNSIDIVGISSLVEKDENELNTIEKPILRGHNEGNQSLISAEPIVVSSDEEGPVEHKSSEILKLQSKQDRETTNENESTSESALLELPLITCESVQMSSELCPYNPVMENISSIMPSNEMDLQLDFIFTSVYIGKIKGASKGCVTITKKYIKIPFQVSLNEISLLVDTTHLKRFGLWKSKDDNHSKRSHAILFFWVSSDYLQEIQTQLEHSVLSQQSKSSEFIFLELHNPVSQREELKLKDIMTEISIISGELELSYPLSWVQAFPLFQNLSSKESSFIHYYCVSTCSFPAGVAVAEEMKLKSVSQPSNTDAAKPTYTFLQKQSSGCYSLSITSNPDEEWREVRHTGLVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEAVYEDFPQTVSQQSQAQQSQNDNKTIDNDLRTTSTLSLSAEDSQSTESNMSVPKKMCKRPCILILDSLKAASVQNTVQNLREYLEVEWEVKLKTHRQFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQQQKGSSS
  
Inhibitor
Name:
BDBM103833
Synonyms:
SPI-08 | US11041859, Code SPI-08 | US9791447, Compound SPI-08
Type:
Small organic molecule
Emp. Form.:
C16H12N3O3S
Mol. Mass.:
326.35
SMILES:
Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c1ccccc1
Structure:
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