Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM504455
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
>1000±n/a nM
Citation
 Crew, AP; Araujo, E Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides US Patent  US11065231 Publication Date 7/20/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM504455
Synonyms:
4-((1s,4s)-4-(4-((2-(2-((2- (2,6-dioxopiperidin-3-yl)- 1,3-dioxoisoindolin-5- yl)oxy)ethoxy)ethyl)sulfonyl) piperazin-1- yl)cyclohexyl)amino) quinazoline-6-carbonitrile | US11065231, Example 35
Type:
Small organic molecule
Emp. Form.:
C36H40N8O8S
Mol. Mass.:
744.817
SMILES:
O=C1N(C2CCC(=O)NC2=O)C(=O)c2cc(OCCOCCS(=O)(=O)N3CCN(CC3)[C@@H]3CC[C@@H](CC3)Nc3ncnc4ccc(cc34)C#N)ccc12 |r,wU:34.39,31.32,(10.83,7,;10.75,5.46,;11.95,4.49,;13.44,4.89,;13.83,6.38,;15.32,6.78,;16.41,5.69,;17.9,6.09,;16.01,4.2,;14.53,3.8,;14.13,2.31,;11.4,3.05,;12.24,1.76,;9.86,3.14,;8.77,2.05,;7.28,2.44,;6.19,1.36,;4.71,1.75,;3.62,.67,;2.13,1.06,;1.04,-.02,;-.45,.37,;-.85,1.86,;.64,2.26,;-1.24,3.35,;-2.33,1.46,;-2.73,-.02,;-4.22,-.42,;-5.31,.67,;-4.91,2.15,;-3.42,2.55,;-6.8,.27,;-7.88,1.36,;-9.37,.96,;-9.77,-.53,;-8.68,-1.62,;-7.19,-1.22,;-11.26,-.93,;-11.66,-2.42,;-10.57,-3.51,;-10.97,-4.99,;-12.45,-5.39,;-13.54,-4.3,;-15.03,-4.7,;-16.12,-3.61,;-15.72,-2.12,;-14.23,-1.73,;-13.14,-2.81,;-16.81,-1.04,;-17.9,.05,;6.88,3.93,;7.97,5.02,;9.46,4.62,)|
Structure:
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